Advancements in Clinical Utilization of Recombinant Human Collagen: An Extensive Review

By Wan, Jovian MBChB^*; Yoon, Song Eun MD^†; Pamela, Ruri MD^‡; Kai Jie Wong, Isaac MD^§; Vitale, Massimo MD^∥; Cartier, Hugues MD^¶; Garson, Sebastien MD^#; Yi, Kyu-Ho MD, PhD^**,††*Medical Research Inc., Wonju
†BRANDNEW Aesthetic Surgery Clinic, Seoul, Korea
‡CELV Dermatology Clinic, Jakarta, Indonesia
§The Artisan Clinic, Singapore
∥Private Practice, Bologna, Italy
¶Centre Médical Saint Jean, Arras, France
#Cabinet Médical, Senlis, France
**Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry
††You and I Clinic, Seoul, Korea

Objective:
This case series evaluates the efficacy and safety of LDE therapy combined with microneedling in patients with active acne, PIH, and atrophic scarring.

Methods:
Three patients with moderate to severe acne [Investigator’s Global Assessment (IGA) scores 2–4], visible PIH, and atrophic scarring underwent biweekly microneedling treatments followed by topical application of LDE (BLESKIN EXXO, Daeyang Medical) over 2 months. Assessments were conducted at baseline and 2-month post-treatment, utilizing the IGA scale for acne severity, the Postinflammatory Hyperpigmentation Area and Severity Index (PIHASI) for PIH, and the Goodman and Baron Scarring Grading System for atrophic scarring. Two independent, blinded dermatologists evaluated clinical photographs and scored all outcomes. Patient satisfaction was recorded on a 10-point Likert scale.

Results:
All patients exhibited significant improvements in acne severity, PIH, and atrophic scarring. IGA scores decreased from baseline values of 3 to 4 to 1 to 2 post-treatment. PIHASI scores were reduced by 4 to 6 points, and Goodman and Baron scores improved by one grade level. Patient satisfaction scores ranged from 8 to 9 out of 10. Minimal adverse events were noted, with only one instance of transient erythema observed during the study.

Conclusion:
LDE therapy combined with microneedling seems to be a promising treatment modality for active acne, PIH, and atrophic scarring, demonstrating significant clinical improvements with high patient satisfaction and minimal adverse effects. Further research with larger cohorts and controlled studies is warranted to validate these findings...."

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